CLM1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G07999 (symbol CLM1) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with a trichodiene synthase domain and an isoprenoid synthase domain superfamily, possessing carbon-oxygen lyase activity acting on phosphates and metal binding. The gene is associated with culmorin anabolism, mycotoxin anabolism, and detoxification. Studies of related genes in other species link the family to the enzyme classes 4.2.3.47 and 4.2.3.-, and to increased virulence (hypervirulence) and fusarium head blight.