CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (CI-1, ERG5) on chromosome 1 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity acting on paired donors, and monooxygenase activity. It is associated with ergosterol and mycophenolic acid anabolism, secondary metabolite biosynthesis, and terpenoid anabolism, and localises to the endoplasmic reticulum membrane. The gene is linked to numerous phenotypes including decreased colony size, increased cell death, arrested vegetative growth, decreased meiosis and cytokinesis, abnormal autophagy and vacuolar transport, delayed G2/M phase transition, and increased budding. Related genes in other species connect the family to cytochrome P450 function.