PRP1 — Fusarium graminearum PH-1

Summary

FgPRP1 (PRP1) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with PRP1_N, Syf1-like, HAT and TPR-repeat domains. The gene is annotated to spliceosomal tri-snRNP assembly, mRNA splicing via the spliceosome, and localises to the nucleus, catalytic step 2 spliceosome, U4/U6.U5 snRNP complex and Prp19 complex. Associations include increased pheromone sensitivity and mating response, decreased X-ray resistance, absent sporulation and invasive growth, increased filamentous growth, delayed G1 cell cycle progression, abnormal spindle morphology, increased lifespan, altered telomere length, and increased innate thermotolerance alongside increased cold sensitivity. Studies of related genes in other species link it to reduced virulence and abnormal cytokinesis.