CHS1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G07327 (CHS1, also known as CHS3B) in Fusarium graminearum PH-1 encodes a chitin synthase with chitin synthase activity, containing chitin synthase N-terminal domains. The gene is associated with cell wall biogenesis and organization, chitin anabolism, hyphal growth, conidia formation, homologous recombination, signal transduction, and response to dsRNA. Its product localizes to the plasma membrane, cell periphery, hyphal tip, porous cell septum, and cross wall. Phenotypic associations include abnormal septum formation, absent septum formation, decreased flocculation, absent cell fusion, abnormal bipolar budding, abnormal chitin deposition, decreased adhesion, increased pheromone sensitivity, abnormal spore wall formation, and altered cell cycle progression. Studies of related genes in other species link the family to reduced virulence and lethal phenotypes.