CKI1 — Fusarium graminearum PH-1

Summary

FgCKI1 (FGRAMPH1_01G07201) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with a CK1 serine/threonine kinase domain and protein kinase activity, and is annotated with protein tyrosine kinase activity, ATP binding, and magnesium binding. This gene is associated with regulation of filamentous growth, hyphal growth, morphogenesis, cell wall organization, endocytosis, vesicle and vacuole fusion, biofilm formation, signal transduction, cellular response to stress and xenobiotic stimuli, and interaction with the host. It is linked to downregulation of bipolar cell polarity and protein localisation to the cell tip, and upregulation of developmental processes. The product localises to the cytoplasm, nucleus, plasma membrane, cell tip, division site, fungal-type vacuole and its membrane, vacuolar lumen, cell periphery, and extracellular vesicles. Phenotypic associations include abnormal vacuolar and Golgi distribution, decreased intracellular transport, premature G2/M transition, arrested G2 phase, increased shmoo formation, and absent biofilm formation and osmotic stress resistance.