PSD2 — Fusarium graminearum PH-1

Summary

FgPSD2 (FGRAMPH1_01G07059) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with phosphatidylserine decarboxylase activity, L-tryptophan decarboxylase activity, phospholipid binding and metal binding, and contains PSD_type2_pro, PSD, PS_Dcarbxylase, C2_dom, C2_domain_sf, EF_Hand_1_Ca_BS, EF_hand_dom and EF-hand-dom_pair domains. The gene is associated with phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and lipid A anabolism, psilocybin biosynthesis, protein autoprocessing, adiposome formation, autophagy, asexual reproduction, and filamentous growth in response to chemical, starvation and biotic stimuli. The product localises to the Golgi, endosome and vacuole membranes, mitochondria, cytosol and cell division sites. Associations include decreased colony size, abnormal pseudohyphal growth, cytokinesis and mitochondrial distribution, arrested cell cycle, absent shmoo formation and pexophagy, and altered apoptosis and autophagy rates. Studies of related genes in other species link the family to phospholipid metabolism and membrane trafficking.