CAG1 — Fusarium graminearum PH-1

Summary

FgCAG1 (FGRAMPH1_01G06995) on chromosome 1 of Fusarium graminearum PH-1 encodes a fungal G-protein alpha subunit, a member of the Fungi_Gprotein_alpha family with GTPase and guanyl-nucleotide binding activities. The gene is associated with heterotrimeric G-protein complex localisation and linked to sexual reproduction, including perithecium development and formation, sporocarp development, and karyogamy. It is also connected to regulation of the pheromone response MAPK cascade, conidium formation, and secondary metabolite biosynthesis, including mycotoxin and sterigmatocystin production. Phenotypic associations include abnormal mating response and efficiency, altered pheromone production, delayed sporulation, and increased pexophagy. Studies of related genes in other species link the family to pathogenicity and virulence.