GCS1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G07003 (GCS1) encodes a protein with a Gln_synth/guanido_kin_cat domain and glutamate-cysteine ligase activity, and binds ATP. In Fusarium graminearum, GCS1 is associated with glutathione and phytochelatin anabolism, cellular responses to cadmium and hydrogen peroxide, and localizes to the cytoplasm, cytosol, nucleus, and glutamate-cysteine ligase complex. The gene is linked to numerous phenotypes including absent oxidative stress resistance, decreased spore germination rate, delayed sporulation, abnormal nucleophagy, altered cell cycle progression, and reduced desiccation resistance. Additional associations include absent fermentative growth, decreased anaerobic growth rate, and increased nutrient uptake. Related genes in other species link the family to oxidative stress response and unaffected pathogenicity, though these relationships are not established for GCS1 itself.