NAT1 — Fusarium graminearum PH-1

Summary

FgNAT1 (NAT1) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with acetyltransferase activator activity and transferase activity, belonging to the NatA auxiliary subunit family and containing tetratricopeptide repeat (TPR) domains. It is a component of the NatA complex and localizes to the cytoplasm, cytosol, and nucleus. The gene is associated with pigmentation, protein maturation, and detoxification. Phenotypic associations link FgNAT1 to abnormal spore germination, delayed vegetative growth, increased fermentative growth, and altered cell cycle progression, including delayed S phase and G2/M transition. It is also connected to premature apoptosis, increased cell death, abnormal nuclear position, and increased mitochondrial rho- mutation frequency. Studies of related genes in other species link the family to oxidative stress response and increased metal resistance.