NTH1 — Fusarium graminearum PH-1

Summary

FgNTH1 (FGRAMPH1_01G06783) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with trehalase activity and alpha,alpha-trehalase activity and calcium ion binding, belonging to the glycosyl hydrolase 37 family. The gene is associated with mycose catabolism and metabolism, ascospore formation, cellular responses to heat and starvation, hyphal growth, and secretion, and localises to the cytoplasm and cytosol. The gene is linked to increased acquired thermotolerance and freeze-thaw resistance, absent biofilm formation and hyperosmotic stress resistance, increased aneuploidy, and altered cell cycle progression, budding patterns, and flocculation. Sequence similarity studies of the trehalase family connect it to reduced virulence in other fungi and to associations with plant pathogens such as Fusarium oxysporum and diseases including fusarium head blight and vascular wilt.