ENA1 — Fusarium graminearum PH-1

Summary

FgENA1 (FGRAMPH1_01G06415) on chromosome 1 of Fusarium graminearum PH-1 encodes a P-type ATPase of the IID subfamily with P-type potassium:proton transporter activity, K+-transporting ATPase activity, and P-type sodium, manganese and calcium transporter activities. The gene is associated with potassium and sodium ion export from the cell, cellular ion homeostasis, calcium transport into the vacuole, proton export across the plasma membrane, cell pH reduction, macroautophagy, and the response to unfolded protein. The product localises to the plasma membrane, cell tip, medial membrane band, vacuolar membrane, Golgi membrane, ER membrane and nuclear envelope. Phenotypic associations include abnormal cell cycle progression, decreased endocytosis, increased anaerobic growth, increased freeze-thaw resistance, decreased necrotic cell death, increased ionic stress resistance, increased starvation resistance, and absent nutrient uptake, meiosis and desiccation resistance. Studies of related genes in other species link the family to sodium and potassium content, and reduced virulence.