PREB — Fusarium graminearum PH-1

Summary

FgPREB (FGRAMPH1_01G06371) on chromosome 1 of Fusarium graminearum PH-1 encodes a STE2-family GPCR with mating-type factor pheromone receptor activity. The gene is associated with mating, chemotropism, hyphal growth, response to host, bioluminescence, and mycotoxin anabolism. Phenotypic associations include absent mating efficiency, abnormal mating response, decreased nuclear fusion during mating, absent cell fusion, increased recovery from pheromone-induced cell cycle arrest, decreased budding, altered endocytosis, and sterile phenotype. The gene is also linked to cell cycle progression, pheromone production and sensitivity, protein transport, and vacuolar transport. Studies of related genes in other species connect the family to reduced virulence and oxidative stress response.