CHS1 — Fusarium graminearum PH-1

Summary

FgCHS1 (FGRAMPH1_01G05957) on chromosome 1 of Fusarium graminearum PH-1 encodes a chitin synthase with chitin synthase activity, containing Chitin_synth_N and Chitin_synth domains. The gene is associated with cell wall biogenesis and organization, chitin anabolism, conidia formation, septum positioning, mitotic actomyosin contractile ring contraction, response to dsRNA, homologous recombination, and signal transduction. Its product localizes to the plasma membrane, cell periphery, cellular bud neck, and cross wall. Phenotypic associations include abnormal chitin deposition, septum formation, bipolar budding, spore wall formation, and cell cycle progression, as well as decreased flocculation, adhesion, and cell fusion, increased pheromone sensitivity, and altered lifespan and survival rate in stationary phase. Related genes in other species link the family to polysaccharide content, reduced virulence, and vegetative growth.