ATG15 — Fusarium graminearum PH-1

Summary

FgATG15 (FGRAMPH1_01G06045) on chromosome 1 of Fusarium graminearum PH-1 encodes a lipase of the ATG15 family, possessing glycerophospholipase activity. The gene is associated with autophagy, lipolysis, neutral lipid and phosphatidylserine breakdown, and multivesicular body (MVB) membrane disassembly. Its product localises to the MVB membrane, vacuolar lumen, and membrane compartments. Phenotypic associations link FgATG15 to abnormal or absent autophagy, nucleophagy, mitophagy, pexophagy, and ribophagy, as well as increased necrotic cell death, altered cell cycle progression, absent filamentous growth, endocytosis, and protein secretion, and decreased colony size. The gene is also associated with increased ionic stress resistance and mating response. Related genes in other species are linked to reduced virulence and delayed autophagy.