CSN5 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G06201 (CSN5, also known as RRI1) encodes a metallopeptidase with deNEDDylase activity, belonging to the JAMM/MPN+ family and the COP9 signalosome (CSN) complex. The gene is associated with protein deneddylation and neddylation, proteolysis, cell cycle modulation, hyphal growth, cleistothecium development, and sexual reproduction. It localizes to the cytoplasm, cytosol, nucleus, and CSN complex. Phenotypic associations include altered shmoo formation, mating efficiency, pheromone sensitivity, cell cycle progression (G1/S arrest or delay, G2/M delay), cell death, cell size, flocculation, adhesion, vegetative growth rate, mitochondrial genome maintenance, peroxisomal distribution and transport, and redox state. Studies of related genes in other species link the CSN5 family to COP9 signalosome function and protein content traits.