SUR2 — Fusarium graminearum PH-1

Summary

FgSUR2 (FGRAMPH1_01G06053) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with a sterol desaturase-related domain and a fatty acid hydroxylase domain, exhibiting sphingolipid delta-4 desaturase activity, sphingolipid C4-monooxygenase activity, and 4-methylsterol oxidase activity. It is associated with MIPC metabolism, MIPC biosynthetic process, sphingolipid anabolism, ergosterol anabolism, and hyphal growth, and localizes to the endoplasmic reticulum membrane. The gene is linked to numerous phenotypes including decreased autophagy and pexophagy, reduced cell cycle progression and entry into G0, absent cell fusion and meiotic recombination, abnormal filamentous and pseudohyphal growth, increased fermentative growth and nutrient uptake, and altered prion inheritance, chitin deposition, and plasma membrane morphology. Studies of related genes in other species connect the family to calcium sensitivity, potassium concentration, phosphate content, and oxidative stress response.