TRX — Fusarium graminearum PH-1

Summary

FgTRX (FGRAMPH1_01G05769) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with a thioredoxin domain and thioredoxin-like superfamily fold, possessing protein-disulfide reductase and antioxidant activities. The gene is associated with cell redox homeostasis, cellular detoxification of hydrogen peroxide, and toxic metabolite repair, as well as peptide secretion, immune response, sexual reproduction, and secondary metabolism. It localises to the cytoplasm, nucleus, vacuole, and nuclear periphery. Phenotypic associations link FgTRX to abnormal colony colour and shape, decreased cell death, increased mating response, altered septum formation and cytokinesis, increased starvation resistance, and absent nutrient uptake and protein secretion. Studies of related genes in other species connect the family to oxidative stress response.