MREA — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G05753, also known as MREA or ZEB1 in Fusarium graminearum PH-1 on chromosome 1, encodes a protein belonging to the FAD-linked oxidoreductase family, specifically the berberine bridge enzyme (BBE) domain, with annotated isomerase activity, FAD binding, and redox activity. The gene is directly associated with the zearalenone biosynthetic process, patulin anabolism, and alkaloid metabolism, and its product localizes to the vacuolar lumen and extracellular. It is linked to mycotoxin content. Studies of related genes in other species connect the family to isoamyl alcohol oxidase activity and, in some cases, to unaffected pathogenicity, though these associations are not established for this specific gene.