NGS1 — Candida albicans

Summary

CR_00190W_A (NGS1) on Candida albicans chromosome 8 encodes a protein with NagZ beta-hexosaminidase and glycoside hydrolase domains, and is annotated with H3 histone acetylase, N-acetyltransferase, O-glucosyl hydrolase, and DNA-binding transcription activator activities. The gene is associated with regulation of carbohydrate utilization, cellular response to N-acetyl-D-glucosamine and nutrients, N-acetylglucosamine breakdown, murein turnover, and carbohydrate metabolism. It is linked to hyphal growth, morphogenesis, phenotypic switching, mating, upregulation of filamentous growth, secondary metabolism, cell death, and symbiotic interaction processes. NGS1 localizes to the nucleus and extracellular space, and is associated with disseminated candidiasis in a mouse model. Related genes in other species link the family to glycosyl hydrolase activity.