LUA — Candida albicans

Summary

CR_00360C_A (LUA, also known as LEU1) on Candida albicans chromosome 8 encodes a 3-isopropylmalate dehydratase, an enzyme with 3-isopropylmalate dehydratase and homoaconitate hydratase activities that binds a 4Fe-4S cluster and metal ions. This gene is associated with L-leucine biosynthesis, riboflavin biosynthesis, the glyoxylate cycle, morphogenesis and its regulation, mitotic recombination, and tRNA processing. The product localises to the isopropylmalate isomerase complex, mitochondrial lumen, and cytosol. Phenotypic associations include decreased anaerobic growth, sporulation, endocytosis, and acid pH resistance, increased telomere length and mutation frequency, altered colony appearance, auxotrophy, and changes in carbon and nitrogen source utilisation, respiratory growth, and stress resistances including decreased hyperosmotic and UV resistance but increased oxidative stress resistance. Studies of related genes in other species link the family to homoaconitate hydratase activity.