RTT109 — Candida albicans

Summary

CR_00410W_A (RTT109) on Candida albicans chromosome 8 encodes a histone acetyltransferase with H3 histone acetylase activity (EC 2.3.1.48), belonging to the histone acetyltransferase Rtt109/CBP family. The gene is associated with nucleosome assembly, DNA replication, repair, and damage response, as well as regulation of DNA-templated transcription. RTT109 is associated with phenotypic switching, including regulation of cell fate determination, filamentous growth, hyphal growth, and biofilm formation. It is also associated with sterol homeostasis and morphogenesis. The protein localizes to chromatin and the nucleus. Studies of related genes in other species link the family to oxidative stress response. Associations with cell cycle progression, sporulation efficiency, chronological lifespan, and chromosome segregation have been reported, though these are not established in C. albicans.