BD — Candida albicans

Summary

CR_02140W_A (BD, RSR1) on Candida albicans chromosome 8 encodes a small GTPase of the Ras-type family, possessing GTPase activity and binding GTP, GDP, CTP and UTP, as well as protein ser/thr kinase activator activity (EC 3.6.5.2). The gene is associated with farnesol anabolism and response, filament development, thigmotropism, cell-cell signaling, cAMP/PKA signaling, response to hypoxia, regulation of morphogenesis, axial bud site selection, cytogamy, and cell-abiotic substrate adhesion. It is linked to numerous phenotypes including absent bipolar budding pattern, decreased vacuolar transport rate, increased mating type switching, decreased redox state, absent osmotic and oxidative stress resistance, decreased budding rate, decreased flocculation, and delayed cell cycle progression in telophase. The protein localizes to the hyphal tip, division septum, cellular bud neck, cell cortex, and fungal-type cell wall. Related genes in other species link the family to oxidative stress response and protein content.