RHO1 — Candida albicans

Summary

CR_02860W_A (RHO1) on Candida albicans chromosome 8 encodes a small GTPase of the Rho family, possessing GTPase activity, GTP and GDP binding, protein ser/thr kinase activator activity, and signaling adaptor activity. RHO1 is associated with the regulation of beta-glucan anabolism, bipolar cell growth, actomyosin contractile ring contraction, endocytic recycling, exocytosis, vesicle-mediated transport, and Rho protein signal transduction. It localizes to the exocytic vesicle, 1,3-beta-glucan synthase complex, cleavage furrow, and cell tips. The gene is linked to candidiasis and oxidative stress response. Phenotypic associations include decreased septum formation, abnormal bipolar budding, absent cell fusion, decreased adhesion, increased shmoo formation rate, and altered protein transport and endocytosis. Related genes in other species link the family to acid sensitivity.