CAP1 — Candida albicans

Summary

CR_04190W_A (CAP1/SRV2) in Candida albicans encodes an adenylyl cyclase-associated protein (CAP) with adenylate cyclase regulator activity, and binds adenylyl cyclase, actin, and identical proteins. The gene is associated with positive regulation of cAMP/PKA signaling, actin filament destabilization and F-actin severing, response to neutral pH, hexose breakdown, detoxification of hydrogen peroxide, autophagy of peroxisomes, mitochondrial fission, and macrophage activation. It has been linked to filamentous growth, budding rate, protein secretion, pheromone sensitivity, chitin deposition, endocytosis, nuclear transport, cell cycle progression, and prion inheritance. Localization evidence connects the product to the growing cell tip, division septum, actin patch, and cytoplasm. Related genes in other species link the CAP family to acid sensitivity.