GPI2 — Candida albicans

Summary

CR_04470W_A (GPI2, CaGPI2) on Candida albicans chromosome 8 encodes a phosphatidylinositol N-acetylglucosaminyltransferase with transglycosidase activity, a component of the GPI-GnT complex localized to the ER membrane. The gene is associated with GPI anchor anabolism, fungal-type cell wall organization, hyphal growth, morphogenesis, sterol and ergosterol anabolism, and sterol homeostasis. Associations with disseminated candidiasis and with Mus musculus have been noted. Phenotypic associations include abnormal flocculation, increased pseudohyphal growth, absent or increased autophagy, increased vegetative growth rate, increased survival in stationary phase, increased hyperosmotic stress resistance, decreased cold sensitivity, increased chitin deposition, and altered cell cycle progression, mating efficiency, sporulation, and protein transport. Related genes in other species link the family to abnormal spore wall formation, endomembrane system morphology, and cellular morphology.