TPS1 — Candida albicans

Summary

CR_05720W_A (TPS1) on Candida albicans chromosome 8 encodes a protein with trehalose synthase activity, trehalose-phosphatase activity, transglucosylase activity, and nucleotide binding, belonging to the Trehalose_OtsA and Glyco_trans_20 domain families. The gene is associated with mycose biosynthesis and metabolism, carbohydrate breakdown, dephosphorylation, and cellular responses to desiccation, heat, hydrogen peroxide, resveratrol, and stress. It is linked to germ tube formation, filamentous growth in response to heat, cell wall biogenesis, ascospore formation, phagocytosis, cell killing, TNF production, and catabolite repression. The product localizes to the cytosol, nucleus, and trehalose-6-phosphate synthase complex. Associations include increased acquired thermotolerance, increased adhesion, absent biofilm formation, decreased hypoosmotic stress resistance, increased freeze-thaw resistance, and absent desiccation resistance. Studies of related genes in other species link the family to sporogenesis, turgor pressure, and calcium and acid sensitivity.