SFL1 — Candida albicans

Summary

CR_05990C_A (SFL1) on Candida albicans chromosome 8 encodes a protein with DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor binding, phosphorelay response regulator activity, and transferase activity, and belongs to the HSF DNA-binding domain family. The gene is associated with negative regulation of flocculation, filamentous growth, germ tube formation, quorum sensing, response to farnesol, response to host, response to singlet oxygen, cellular thermotolerance, cell differentiation, cell size control, and regulation of the unfolded protein response. It localizes to the nucleus, chromatin, and RNA polymerase II transcription regulator complex. Studies of related genes in other species link the family to reduced virulence and candidiasis.