PPZ1 — Candida albicans

Summary

CR_06420W_A (PPZ1) on Candida albicans chromosome 8 encodes a serine/threonine protein phosphatase with RNA polymerase II C-terminal domain T4 phosphatase activity and metal binding capacity, belonging to the PP1 catalytic subunit family. This gene is associated with regulation of ferroptosis, fatty acid oxidation, cell budding, glycogen anabolism, clathrin-mediated endocytosis, anisotropic cell growth, cell polarization, centromere clustering, TORC1 signaling, and protein dephosphorylation. It localizes to the DPS complex, cellular bud neck septin collar, protein serine/threonine phosphatase complex, PTW/PP1 phosphatase complex, mating projection base, and euchromatin. PPZ1 is linked to oxidative stress response, biofilm formation, filamentous and pseudohyphal growth, hyperosmotic stress resistance, cell cycle progression, endocytosis, vacuolar transport, and necrotic cell death. Related genes in other species connect the family to potassium concentration.