FHPA — Candida albicans

Summary

CR_07790C_A (FHPA, also known as YHB1) on Candida albicans chromosome 8 encodes a protein with globin and flavoprotein reductase domains, exhibiting nitric oxide dioxygenase [NAD(P)H] activity, cytochrome-b5 reductase activity acting on NADH and NAD(P)H, NADH dehydrogenase activity, transferase activity, FAD binding, and heme binding. The gene is associated with response to nitrosative stress, nitric oxide breakdown, alternative respiration, regulation of the glyoxylate cycle, gluconeogenesis, germ tube formation, phenotypic switching, cell adhesion, phagocytosis, and sterol metabolism. It localises to the mitochondrial outer membrane, ER, cytoplasm, cytosol and nucleus. Phenotypic associations include decreased fermentative and respiratory metabolism, increased pheromone sensitivity and flocculation, abnormal budding, increased autophagy, decreased gamma ray resistance, increased hyperosmotic stress resistance, absent pseudohyphal growth, and cell cycle arrest at both G1 and G2/M phases. Related genes in other species link the family to oxidative stress response and toxin resistance.