NMT1 — Candida albicans

Summary

CR_09290W_A (NMT1, also known as THI13) on Candida albicans chromosome 8 encodes a member of the NMT1/THI5 and SsuA/THI5 protein families with 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP, a metal-binding enzyme in thiamin and TPP biosynthesis. This gene is associated with thiamin metabolism and anabolism, as well as immune response processes including IL-12 and IL-10 production. It has been linked to pseudohyphal and hyphal growth, filamentous growth, cell growth, cell death, and signal transduction. The encoded protein localizes to both the cytosol and nucleus. Studies of related genes in other species connect the family to thiamin biosynthesis, while sequence similarity links to phenotypes including decreased sporulation, altered chemical compound accumulation, abnormal vacuolar morphology, reduced vegetative growth, decreased competitive fitness, and decreased chemical resistance.