OGM1 — Candida albicans

Summary

CR_09770C_A (OGM1, also known as PMT5) on Candida albicans chromosome 8 encodes a protein O-mannosyltransferase (EC 2.4.1.109) with protein O-mannosyltransferase activity, mannosyltransferase activity, transglycosidase activity, and identical protein binding. The product belongs to the PMT_4TMC, ArnT-like_N, and MIR motif families. OGM1 is associated with protein O-linked glycosylation, fungal-type cell wall organization, filamentous growth, hyphal growth, biofilm formation, cell-substrate adhesion, interaction with host, immune response, calcium signaling, and regulation of erUPR. It is linked to the dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer and localizes to the ER membrane, endomembrane system, nuclear membrane, and plasmalemma. The gene is associated with mannose content, oxidative stress response, and traits including delayed exponential-phase growth, abnormal chitin deposition, and decreased fermentative metabolism. Studies of related genes in other species link the family to loss of pathogenicity.