SOR1 — Candida albicans

Summary

CR_10840C_A (SOR1, also known as XYL2) on Candida albicans chromosome 8 encodes a protein with L-iditol 2-dehydrogenase and D-xylulose reductase activities, belonging to the SDH-like and ADH-like families. The gene is associated with xylitol breakdown to xylulose 5-phosphate, D-xylose metabolism, sorbitol breakdown, glycerol metabolism, fructose anabolism, NADPH regeneration, the pentose-phosphate shunt, ethanol fermentation, and cell growth. It has been linked to increased fermentative growth, decreased anaerobic growth, decreased hyperosmotic and oxidative stress resistance, altered chemical compound accumulation, increased chronological lifespan, and both increased and decreased competitive fitness. The encoded protein localises to the cytosol, hyphal cell wall, and extracellular space. Studies of related genes in other species link it to xylitol dehydrogenase activity.