SOD2 — Candida albicans

Summary

C1_01520C_A (SOD2) on Candida albicans chromosome 1 encodes a manganese/iron superoxide dismutase (EC 1.15.1.1) with superoxide dismutase activity, manganese binding and IgE binding. The gene is associated with the mitochondrial lumen, mitochondria and cytosol, and is linked to reactive oxygen species metabolic process, evasion or tolerance of host-produced AOS, response to host, metabolic burst, germ tube formation, quorum sensing, wound healing, response to glutathione, regulation of K+ transport, response to glucose, glycerol anabolism, ATP anabolism, protein unfolding, innate immunity, and cellular response to lithium ion. Associations include candidiasis, oxidative stress response, and photosynthetic rate. Phenotypic connections include anaerobic growth, respiratory metabolism, mating type switching, necrotic cell death, cell cycle progression, stationary phase entry, radiation resistance, alkaline pH resistance, and hydrostatic pressure resistance. Related genes in other species are linked to sodium concentration, manganese content, and acid sensitivity.