ABCA — Candida albicans

Summary

C1_01920W_A (ROA1, also known as ABCA) in Candida albicans encodes an ABCG-family transporter with ABC-type xenobiotic transporter activity, ATP-coupled transmembrane transporter activity, and ATP hydrolase activity. The gene is associated with azole transmembrane transport, xenobiotic detoxification by transmembrane export across the plasma membrane, and response to progesterone. It is linked to sterol homeostasis, TOR signaling, calcium signaling, nitrogen catabolite repression, and inflammatory response. The protein localizes to the plasma membrane, vacuolar membrane, and vacuolar lumen. Phenotypic associations include abnormal small molecule transport, increased vacuolar transport, decreased cell death rate, increased fermentative growth, abnormal pseudohyphal growth, and altered replicative and chronological lifespan. Studies of related genes in other species connect the family to plant height, root length, drought tolerance, and oxidative stress response.