AARA — Candida albicans

Summary

C1_02820W_A (AARA/LYS2) on Candida albicans chromosome 1 encodes a protein with L-aminoadipate-semialdehyde dehydrogenase activity (EC 1.2.1.31, EC 1.2.1.95), ligase activity, oxidoreductase activity, and phosphopantetheine binding, containing thioester reductase-like, AMP-binding, and acyl carrier protein domains. The gene is associated with lysine and amino acid anabolism, secondary metabolite biosynthesis, and amino acid activation for nonribosomal peptide biosynthetic processes. It localises to the cytoplasm and cytosol. AARA is associated with filamentous growth, decreased osmotic stress resistance, decreased acquired thermotolerance, decreased survival in stationary phase, increased sporulation efficiency, abnormal cell cycle progression, decreased mitophagy and pexophagy, abnormal vacuolar and peroxisomal transport, and altered endocytosis. Related genes in other species connect the family to nitrogen source utilisation and protein content traits.