CSH1 — Candida albicans

Summary

CSH1 (C1_04020C_A) on chromosome 1 of Candida albicans encodes a protein with an aldo-keto reductase domain and exhibits aryl-alcohol dehydrogenase (NAD+) activity, versiconal reductase activity, hydroxyversicolorone reductase activity, and versiconal hemiacetal acetate reductase activity. The gene is associated with biofilm formation, hyphal growth, invasive growth, morphogenesis, quorum sensing, cell adhesion, cell-matrix adhesion, immune evasion, secretion, digestion, oxidative phosphorylation, vitamin anabolism, cysteine anabolism, potassium ion membrane transport, iron transport, and oxidative stress response. Its product localizes to the hyphal cell wall, fungal biofilm matrix, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence and increased chemical resistance.