DUR1 — Candida albicans

Summary

C1_04660W_A (DUR1, CaDUR1) on Candida albicans chromosome 1 encodes a protein with urea carboxylase (EC 6.3.4.6) and allophanate hydrolase (EC 3.5.1.54) activities, and also exhibits acetyl-CoA carboxylase, biotin carboxylase and pyruvate carboxylase activities. The gene is associated with urea metabolism and breakdown, proline breakdown and metabolism, nitrogen catabolite repression, nitrogen utilization, malonyl-CoA anabolism, arginine metabolism, the glyoxylate cycle, amino acid import, germ tube formation, tube formation, mitotic nuclear membrane biogenesis, the inflammatory response, innate immunity, cellular response to basic pH, and generation of precursor metabolites and energy. The product localizes to mitochondria, the cytoplasm and the cytosol. Phenotypic associations include decreased osmotic stress resistance, decreased gamma ray and freeze-thaw resistance, increased fermentative metabolism, abnormal cell cycle progression, and arrested vegetative growth.