CAT1 — Candida albicans

Summary

C1_06810W_A (CAT1) on Candida albicans chromosome 1 encodes a catalase (EC 1.11.1.6) with heme-binding and metal-binding activity, belonging to the catalase clade 1/3 family. The enzyme is localized to peroxisomes, mitochondria, and the cytoplasm. CAT1 is associated with hydrogen peroxide detoxification, oxidative stress response, and regulation of morphogenesis, germ tube formation, quorum sensing, cell-cell signaling, and nitrogen utilization. It has been linked to traits including oxidative stress response. Phenotypic associations connect CAT1 to decreased fermentative metabolism, increased pexophagy, and increased ionic stress resistance. Studies of related genes in other species link the family to responses against pathogens such as Fusarium oxysporum and Verticillium dahliae.