CCR4 — Candida albicans

Summary

C1_08220W_A (CCR4, also known as NGL1 or CaCCR4) in Candida albicans chromosome 1 encodes a poly(A)-specific RNase with 3'-5' exoribonuclease activity, belonging to the CCR4/nocturin mRNA transcription domain family and the endo/exonuclease/phosphatase superfamily. The gene is associated with the CCR4-NOT core complex and Paf1 complex, localizing to the cytoplasm, nucleus, and P bodies. It is linked to numerous biological processes including mRNA poly(A) tail shortening, negative regulation of gene expression, immune response and evasion, T-helper cell differentiation, IL-17 and IL-10 production, cell wall biogenesis, phospholipid homeostasis, and DNA replication checkpoint control. Phenotypic associations include increased virulence, altered cell cycle progression (including premature G2/M transition and increased rate through START), decreased budding, increased sporulation, delayed fermentative metabolism, decreased polyploidy, abnormal aneuploidy, and altered replicative lifespan.