UPC2 — Candida albicans

Summary

C1_08460C_A (UPC2, also known as CaECM22 or CaUPC2) in Candida albicans chromosome 1 encodes a Zn2-C6 fungal-type DNA-binding transcription factor. The gene is associated with DNA-binding transcription repressor activity, RNA polymerase II-specific, transcription cis-regulatory region binding, and DNA binding. It is linked to the regulation of ergosterol biosynthesis, sterol metabolism and import, cholesterol anabolism, and cAMP anabolism. It is associated with responses to hypoxia, sulfur amino acid metabolism, fungal-type cell wall biogenesis, and programmed cell death including pyroptotic cell death. Associations with immune evasion, IL-1 production, and phagocytosis connect it to host-pathogen interactions. The gene is also linked to disseminated candidiasis in mouse models. Phenotypic associations include abnormal budding, shmoo formation, filamentous growth, mating response, pheromone sensitivity, chitin deposition, septum formation, vesicle distribution, plasma membrane morphology, mitochondrial genome maintenance, pexophagy, and increased survival rate in stationary phase. The protein localizes to the nucleus and chromatin.