AOX — Candida albicans

Summary

C1_09160W_A (AOX1, also known as CaAOX) in Candida albicans encodes an alternative oxidase, a member of the AOX superfamily, with alternative oxidase activity and metal binding. This mitochondrial inner membrane protein is associated with alternative respiration, the electron transport chain, cellular respiration, and ATP and cAMP anabolism. It is linked to programmed cell death, apoptosis, mitophagy, biofilm formation, immune evasion, and phagocytosis, as well as cellular responses to iron, gluconeogenesis, and the metabolism of methanol, sphingolipids, and sterols. Related genes in other species are associated with reduced virulence and oxidative stress response, though these associations are not yet established for this specific gene.