CPP1 — Candida albicans

Summary

C1_10000C_A (symbol CPP1) on Candida albicans chromosome 1 encodes a dual-specificity MAP kinase phosphatase (EC 3.1.3.48) with protein tyrosine/threonine phosphatase activity. The gene is associated with negative regulation of the cell integrity MAPK cascade, negative regulation of filamentous growth, chlamydospore formation, and downregulation of MAPK cascade. It is also associated with upregulation of DNA replication, protein kinase A activation, amino acid breakdown, thiamin anabolism, phospholipid anabolism, pheromone response, cell wall biogenesis, homologous recombination, and dephosphorylation. The product localises to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence and associations with candidiasis and mycotic mastitis.