TBP — Candida albicans

Summary

C1_10660W_A (TBP1, symbol TBP) in Candida albicans encodes a TATA-box-binding protein, a core component of the transcription factor TFIID, TFIIA, TFIIIB, and RNA polymerase I regulator complexes. The protein exhibits DNA-binding, chromatin-binding, and transcription factor-binding activities, and is associated with transcription initiation by all three RNA polymerases, preinitiation complex assembly, and telomere maintenance. TBP1 is associated with biofilm formation, cell growth, ergosterol metabolism, and the positive regulation of RNA polymerase II transcription. Phenotypic associations link the gene to cell cycle progression through G1/S and metaphase/anaphase, meiosis, mating-type switching, shmoo formation, pheromone sensitivity and production, adhesion, desiccation resistance, ribophagy, and anaerobic growth. Related genes in other species connect it to general transcription factors such as BRF1, TAF12, and NCB2.