DLH1 — Candida albicans

Summary

C1_12560C_A (DLH1) in Candida albicans chromosome 1 encodes a recombinase with ATP hydrolase activity, ATP-dependent DNA damage sensor activity, and ATPase inhibitor activity, and belongs to the RecA-like DNA recombination/repair protein family. The gene is associated with meiotic strand invasion, reciprocal meiotic recombination, double-strand break repair, mating-type switching, and mitotic recombination. It localizes to the nucleus, chromatin, condensed nuclear chromosome, centromere complex, and sites of double-strand breaks. Phenotypic associations include absent X-ray resistance, absent mitotic recombination, absent sporulation efficiency, delayed exponential-phase growth, abnormal spore germination, and altered cell cycle progression through G1/S and metaphase-anaphase transitions. Studies of related genes in other species link the family to meiotic recombination and DNA repair processes.