SPA2 — Candida albicans

Summary

C1_12620W_A (SPA2, CaSPA2) in Candida albicans chromosome 1 encodes a protein belonging to the Spa2/Sph1 family with GIT1_C and GIT_SHD domains. The gene is associated with MAP kinase scaffold activity and is linked to establishment or maintenance of cytoskeleton polarity, cellular bud site selection, actin nucleation, localization, bipolar bud site selection, protein localization, polar cell growth, cell polarization, actin polymerization, nuclear movement, actin cytoskeleton organization, pseudohyphal growth, filamentous growth of a population of unicellular organisms, invasive growth, hyphal growth, mating, secretion, and morphogenesis. It localizes to the cellular bud tip polarisome, cellular bud neck polarisome, hyphal tip polarisome, CAR, actomyosin contractile ring intermediate layer, cell cortex of growing cell tip, hyphal tip, site of polarized growth, cellular bud tip, and mitotic actomyosin contractile ring. Phenotypic associations include abnormal mating efficiency, cell cycle progression, budding rate, septum formation, nuclear fusion, recovery from pheromone-induced arrest, pexophagy, prion inheritance, and thermotolerance. Related genes in other species link the family to protein content.