SC — Candida albicans

Summary

C1_13870W_A (SC, MET3) in Candida albicans encodes a protein with ATP:sulfate adenylyltransferase and adenylylsulfate kinase activities (EC 2.7.7.4), placing it in the sulfate adenylyltransferase/APS kinase family. The gene is associated with numerous biological processes including cysteine, hydrogen sulfide, inositol and mannan anabolism, germ tube and chlamydospore formation, flocculation, pseudohyphal growth, vacuole inheritance, spindle organization and checkpoint control, and mitochondrial DNA metabolism and localization. Phenotypic associations link the gene to increased or absent pseudohyphal growth, altered autophagy, increased hyperosmotic stress resistance, decreased cold sensitivity, altered respiratory and fermentative metabolism, increased vegetative growth rate and viability, abnormal endomembrane system morphology, increased telomere length, and altered prion inheritance. The protein localizes to the cytoplasm. Studies of related genes in other species connect the family to sulfate assimilation.