BIP1 — Candida albicans

Summary

C2_01120W_A (BIP1, also known as KAR2) in Candida albicans encodes a protein of the Hsp70 family, possessing ATP hydrolase activity, peptide binding, and protein translocase activity. It is associated with protein folding and refolding, the unfolded protein response, ERAD pathway, secretion, and cell wall beta-glucan biosynthesis. The gene is linked to the ER lumen, chaperone complexes, and also the hyphal cell wall and biofilm matrix. Phenotypic associations include increased adhesion, abnormal nuclear fusion during mating, delayed cell cycle progression, increased polyploidy and aneuploidy, altered autophagy and endocytosis, and changes in cell death. Studies of related genes in other species link the family to oxidative stress response and hydrogen peroxide content.