CLB1 — Candida albicans

Summary

C2_01410C_A (CLB1, also known as CLB2 or CaCLB2) in Candida albicans chromosome 2 encodes a cyclin A/B-like protein with cyclin-box domains and is associated with cyclin-dependent protein serine/threonine kinase activator and regulator activity. This gene is associated with the regulation of mitotic cell cycle phase transitions, including G1/S and G2/M transitions, mitotic entry, and the traversing of the Start control point. It is linked to the release of cytochrome c from mitochondria, negative regulation of ascospore formation and meiotic cell cycle, and modulation of filamentous growth in response to neutral pH. Phenotypic associations include altered cell cycle progression rates, abnormal mating type switching, absent septum and spore wall formation, premature apoptosis, increased polyploidy and gamma ray resistance, and decreased flocculation and spore germination. The gene product localizes to the microtubule organizing center, mitotic and meiotic spindles, nucleoplasm, and nuclear periphery.