RAD30 — Candida albicans

Summary

C2_03540W_A (RAD30, also known as RAD32) in Candida albicans chromosome 2 encodes a DNA polymerase eta family member with DNA-directed DNA polymerase activity, damaged DNA binding, zinc binding and protein acetylase activity. The gene is associated with the DNA damage response, DNA repair, bypass DNA synthesis, mutagenic post-replication repair, response to radiation and methyl methanesulfonate, meiotic and mitotic sister chromatid cohesion, cell growth mode switching from budding to filamentous, hyphal growth, morphogenesis, phagocytosis, and chromosome division. It localises to the replication fork, nuclear replication fork, site of double-strand breaks, chromatin, mitochondria and nucleus. Phenotypic associations include abnormal mating response, absent mutation frequency and UV resistance, increased necrotic cell death, arrested meiosis and cell cycle progression, delayed meiotic recombination and sporulation, and abnormal telomere length and shmoo formation. The gene is also linked to candidiasis.