SCH9 — Candida albicans

Summary

C2_03940C_A (SCH9) in Candida albicans encodes a serine/threonine protein kinase with protein kinase C activity, belonging to the AGC kinase family and containing a C2 domain. It is associated with lipid and zinc binding, ATP binding, and localizes to the cytoskeleton, sites of polarized growth, stress granules, division septum, nuclear envelope, and fungal-type vacuole membrane. SCH9 is associated with responses to hypoxia, osmotic stress, and host interactions, as well as regulation of filamentous growth, TORC2 signaling, sphingolipid biosynthesis, cell integrity MAPK cascade, and ribosomal protein gene transcription. It has been linked to cell cycle progression, apoptosis, oxidative stress resistance, nutrient uptake, alkaline pH resistance, thermotolerance, and spore germination. Studies of related genes in other species link the family to oxidative stress response and unaffected pathogenicity.